Name | 2-Iodobenzoic acid |
Synonyms | 'LGC' (4009) 2-iodobenzoate IODOBENZOIC-2 ACID ACID O-IODOBENZOIC o-Iodobenzoic acid 2-IODOBENZOIC ACID 2-Iodobenzoic acid O-IODOBENZOIC ACID RARECHEM AL BO 0686 2-IODO BENZONIC ACID BENZOIC ACID, 2-IODO- sodium 2-iodobenzoate 2-IODOBENZOIC ACID pure |
CAS | 88-67-5 |
EINECS | 201-850-7 |
InChI | InChI=1/C7H5IO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)/p-1 |
InChIKey | CJNZAXGUTKBIHP-UHFFFAOYSA-N |
Molecular Formula | C7H5IO2 |
Molar Mass | 248.02 |
Density | 2.25 |
Melting Point | 160-162°C(lit.) |
Boling Point | 313.9±25.0 °C(Predicted) |
Flash Point | 143.6°C |
Water Solubility | sparingly soluble |
Solubility | Ethanol |
Vapor Presure | 0.000205mmHg at 25°C |
Appearance | White to light yellow solid |
Color | Light yellow to orange-brown |
Merck | 14,5030 |
BRN | 1861406 |
pKa | 2.85(at 25℃) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
Sensitive | Light Sensitive |
MDL | MFCD00002419 |
Physical and Chemical Properties | Density 2.25 melting point 160-164°C water-soluble sparingly soluble |
Use | For Organic synthesis |
Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DH2975000 |
TSCA | T |
HS Code | 29163900 |
Hazard Note | Irritant |
Hazard Class | IRRITANT, LIGHT SENS |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Introduction | 2-iodobenzoic acid is also known as O-iodobenzoic acid, O-iodobenzoic acid and its derivatives are important pharmaceutical and chemical raw materials, it is a necessity for the synthesis of all kinds of high iodine reagents. |
Application | 2-iodobenzoic acid is an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
preparation | synthesis of O-iodobenzoic acid: 1. The mercuric reaction will be 7. 4 G (0.05 mol) phthalic anhydride (I) was added to 300 mL(NaOH )= 0.5mol/L aqueous solution, and heated to reflux until the solid was completely dissolved, then, an appropriate amount of acetic acid is added to neutralize the excess alkali until the solution is weakly acidic and II precipitates. Another 11. 0 g (0.055mol) mercury oxide was added to acetic acid solution (acetic acid 25ml, water 50M L), heated to reflux until the solid was completely dissolved to obtain mercury acetate solution, and added to the suspension of the above II, additional 10ml acetic acid was added for acidification, reflux for 24 h, and then cooled and filtered to obtain white solid Ⅲ 15. 6G, washing, drying, namely the phthalic acid decarboxylation of Mercury product III, melting point> 350 deg C, the yield of 98%. 2. Iodination reaction 15. 6g (0.048mol) of the above white solid III and 13g(0.050mol) of iodine were added to a 200mL (0.50mo l/L) KI aqueous solution and heated under reflux for 15H. The reaction mixture was cooled, and the solid insoluble matter was filtered off. 20ml (0.5mol/L) of sodium thiosulfate aqueous solution was added to the filtrate, stirred for a moment, and then acidified with hydrochloric acid, the white solid was filtered, washed with water, dried and recrystallized from ethanol to obtain 10.3g of O-iodobenzoic acid Ⅳ. The total yield was 82. 5%. The melting point was determined to be 164 °c (literature value 163 °c). |
Use | is used in organic synthesis or as an analytical reagent. |
production method | is obtained by diazotization and substitution of anthranilic acid. The anthranilic acid is diazotized with sodium nitrite in the presence of sulfuric acid, and the temperature is controlled below 10 ℃. After the diazo solution is filtered, the mixed solution of potassium iodide and sulfuric acid is added, stirred for 10min and boiled. It is filtered, washed with sodium thiosulfate solution, and recrystallized with water to obtain the finished product. |